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The 4F-MPH mixture was about two times as strong as MPH at DAT and Internet, Despite the fact that addition of your fluorine atom to the four-place of the phenyl ring did not raise potency at SERT.
The proposed pathways are proven in Determine 3. In the mass spectra of both of those racemates, the fragment observed at m/z
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4F-MPH is assumed to act largely being a dopamine and norepinephrine reuptake inhibitor, which means it successfully boosts the amounts of dopamine and norepinephrine neurotransmitters inside the Mind by binding to and partially blocking the transporter proteins that Typically clear these catecholamines with the synaptic cleft.
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